Motus Therapeutics

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PUBLISHED RESEARCH

Acosta A, Camilleri M, Kolar G, Iturrino J, Szarka L, Boldingh A, Burton D, Ryks M, Rhoten D, Zinsmeister AR, Spence S, Gottesdiener K, Vazquez-Roque ML. A Phase II Placebo-Controlled Trial of Efficacy, Safety, and Pharmacodynamics of Relamorelin in Chronic Constipation. American College of Gastroenterology 2014 Annual Scientific Meeting (ACG 2014), October 21, 2014.

Van der Ploeg L, Laken H, Sharma S, Datta R, HalemH, Dong J, Touvay C, Teillot M, Noonan P, Tartaglia L, Stoner L, Henderson B, Gottesdiener K, Culler M. Preclinical Gastrointestinal Prokinetic Efficacy and Endocrine Effects of the Ghrelin Mimetic RM-131. Life Sci. 2014 Jul 25, 109(1):20-9. doi: 10.1016/j.lfs.2014.06.003.

Acosta A, Kolar G, Iturrino J, Szarka L, Boldingh A, Burton D, Ryks M, Rhoten D, Zinsmeister AR, Camilleri M. A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose, Parallel-Group Study to Evaluate the Pharmacodynamics of RM‑131 in Patients with Chronic Constipation. Digestive Disease Week, May 3, 2014.

Sha L, Farrugia1 G, Van der Ploeg LHT, Szurszewski JH. Effect of RM-131 on Circular Smooth Muscle Cells in Human and Mouse Colon and on Colonic Intraluminal Pressure in Conscious Mice. Digestive Disease Week, May 3, 2014.

Kaplan LM, McCallum R, Koch K, Sederman R, Henderson B. High Prevalence and Underdiagnosis of Gastroparesis Symptoms Among Patients with Type 1 and Type 2 Diabetes Mellitus. Digestive Disease Week, May 20, 2013.

Shin A, Camilleri M, Busciglio I, Burton D, Smith SA, Vella A, Ryks M, Rhoten D, Zinsmeister AR. Phase 1, Randomized, Placebo-Controlled, Single-Dose, Two-Period, Crossover Study of RM-131 on Pharmacodynamics and Symptoms in Type 1 Diabetics with Documented Delayed Gastric Emptying. Digestive Disease Week, May 20, 2013.

Shin A, Camilleri M, Busciglio I, Burton D, Smith SA, Vella A, Ryks M, Rhoten D, Zinsmeister AR. The Ghrelin Agonist RM-131 Accelerates Gastric Emptying of Solids and Reduces Symptoms in Patients with Type 1 Diabetes Mellitus.Clin Gastroenterol Hepatol. 2013 Apr 29 [Epub ahead of print]. PubMed PMID: 23639598. doi: 10.1016/j.cgh.2013.04.019.

Shin A, Camilleri M, Busciglio I, Burton D, Stoner E, Noonan P, Gottesdiener K, Smith SA, Vella A, Zinsmeister AR. Randomized Controlled Phase Ib Study of Ghrelin Agonist, RM-131, in Type 2 Diabetic Women With Delayed Gastric Emptying: Pharmacokinetics and pharmacodynamics. Diabetes Care. 2012 Sep 6 [Epub ahead of print]. PubMed PMID: 22961573. doi: 10.2337/dc12-1128.

Datta R, Soulard C, Teillot M, Touvay C, Halem H, Dong J, Culler M. RM-131: A Potent Gastroprokinetic Agent. Digestive Disease Week, May 7, 2011.

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